Optimization and green synthesis of zinc oxide nanoparticle using Garcinia cambogia leaf and evaluation of their antioxidant and anticancer property in kidney cancer (A498) cell lines

Introduction and Aim: In 21stcentury, nanomedicine has turned out to be an emergent modulus operation for the diagnosis treatment of cancer. The current study includes optimization green synthesis zinc oxide nanoparticles from leaves Garcinia cambogia interpretation its antioxidant anticancer activity.
 
 Materials Methods: Synthesized ZnO NPs were investigated by UV–vis, FTIR, XRD, SEM, EDX, HR-TEM, SAED, particle size distribution DLS analysis. Furthermore, different assays conducted evaluating activity (ZnO NPs) using (A498) cell lines along with non-cancerous (HEK-293) line MTT assay XTT assay.
 Results: UV–visible spectrum showed absorption peak at 277 nm that reflects surface plasmon resonance (SPR) ZnONPs. presence various functional groups was confirmed FTIR XRD patterns indicated had a single-phase nature wurtzite structure. TEM pictures shape synthesized Nanoparticles ranges 11–32 mostly hexagonal forms. Zeta potential value 57.9 mV revealed charge cytotoxicity concentrations (6.25 200 µg/mL) measured in line. After exposure, assay, cellular morphology studies cancer viability decreased increasing NP concentration.
 Conclusion: ZnONPs via synthetic route could developed as anti-cancer agent against cells.